|Obesity Triples Chronic Renal Failure Risk
Chronic renal failure is an escalating health problem
throughout the world.
REVIEWED BY ELISABETH EJERBLAD, MD
|Obesity is an important and potentially preventable risk factor for chronic renal failure (CRF), according to a study in the Journal of the American Society of Nephrology. “Our results confirm an accumulating body of clinical and experimental data implicating obesity as an important causative factor in kidney disease, said Elisabeth Ejerblad, MD, of Uppsala University, Sweden, lead author of the study.
NEEDED RESEARCH ON LINK BETWEEN OBESITY, CRF
The investigators said few large-scale epidemiologic studies have quantified the possible link between obesity and CRF. They analyzed anthropometric data on 926 patients from a nationwide, population-based, case-control group of patients with incident, moderately severe CRF. A group of 989 participants with normal kidney function was studied for comparison.
Included patients were all native Swedes who were aged 18 to 74 years, had CRF and whose serum creatinine levels for the first time and permanently exceeded 3.4 mg/dL (men) or 2.8 mg/dL (women) during the study period. Face-to-face interviews, supplemented with self-administered questionnaires, provided information about anthropometric measures and other lifestyle factors, the investigators wrote.
Logistic regression models with adjustments for several cofactors estimated the relative risk for CRF in relation to body mass index (BMI). Overweight (BMI ≥25 kg/m2) at age 20 years was associated with a significant threefold excess risk for CRF, relative to BMI <25 kg/m2. Obesity (BMI ≥30 kg/m2) among men and morbid obesity (BMI ≥35 kg/m2) among women anytime during lifetime was linked to three- to fourfold increases in risk, according to their abstract.
STRONGEST ASSOCIATION WITH NEPHROPATHY
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